GYNECOMASTIA, Causes, Signs and Symptoms, Diagnosis and Treatment. March 21, 2021 cbdnews How Marijuana Works Comments Off on GYNECOMASTIA, Causes, Signs and Symptoms, Diagnosis and Treatment. Gynecomastia (also spelled Gynaecomastia) is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.